Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis
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چکیده
منابع مشابه
Activity of the novel immunomodulatory compound tucaresol against experimental visceral leishmaniasis.
Tucaresol, a novel immunomodulator, was inactive against Leishmania donovani amastigotes in both peritoneal and bone marrow macrophages in vitro at concentrations between 100 and 1 microM, with toxicity to macrophages and parasites at 300 microM. However, against L. donovani in BALB/c mice at doses between 80 and 1.25 mg/kg of body weight administered once daily by the oral route during days 7 ...
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Decoctions, macerations and fumigations of the stem bark and wood of Terminalia brownii 20 Fresen. are used in traditional medicine for fungal infections and as pesticides on field crops and in 21 traditional granaries in Sudan. In addition, T. brownii is commonly used for protecting wooden 22 houses and furniture. Therefore, using agar disc diffusion and macrodilution methods, eight extracts 2...
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Acacia mellifera has been used widely in traditional African medicines against various diseases. Among the Kipsigis community of Kenya, water extracts from the plant is used for the treatment of skin diseases, coughs and gastrointestinal ailments. The aim of the study was to provide scientific rationale for the use of the plant in traditional medicine through bioassay-guided fractionation of A....
متن کاملPentacyclic Triterpenes in Euphorbia microsciadia with Their T-cell Proliferation Activity
The ethyl acetate partition of dried methanolic extract of aerial parts of Euphorbia microsciadia (Euphorbiaceae) afforded three pentacyclic triterpenes, betulinic acid (1) from lupane type, oleanolic acid (2) from oleane type and ursolic acid (3) from ursane type triterpenes that are reported for the first time in this plant. These three compounds were structurally compared through their mass ...
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ژورنال
عنوان ژورنال: Journal of Immunology Research
سال: 2021
ISSN: 2314-7156,2314-8861
DOI: 10.1155/2021/6671287